Monocyte cytotoxicity during acute kidney graft rejection in rats

Monocyte cytotoxicity during acute kidney graft rejection in rats.

Surface antigens, mRNA expression patterns and intravascular accumulation suggested that monocytes might directly participate in acute renal allograft rejection in rats. A flow cytometry-based cytotoxicity assay was used in the present study to analyze the cytotoxic activity of monocytes from the renal and the whole extrapulmonary vasculature of kidney graft recipients (DA to LEW or LEW to LEW)...

Molecular phenotypes of acute rejection predict kidney graft prognosis.

Earlier detection of antibody-mediated rejection of kidney allografts may improve graft outcomes. Profiling of gene expression holds promise for the diagnosis and prognosis of antibody-mediated rejection. Here, we identified 730 patients who received kidney transplants during 2002-2005, including 21 patients (2.9%) who experienced early acute antibody-mediated rejection. We also identified a ma...

cytomegalovirus and acute rejection in kidney transplantation

Dynamic expression of Qa-2 during acute graft rejection.

Human leukocyte antigen (HLA)-G exhibits immunotolerogenicity and is related to allograft acceptance. Qa-2 is the murine homolog of HLA-G; it has structure and functions similar to those of HLA-G. We investigated the dynamic expression of Qa-2 in skin allografts by immunohistochemistry and on peripheral blood lymphocyte subsets by flow cytometry during the entire process of acute graft rejectio...

Molecular Phenotypes of Kidney Graft Rejection

In the last decade, gene expression studies of kidney transplants provided an opportunity to better understand the development and regulation of kidney graft rejection. This review outlines the progress in the definition of biomarkers of rejection and, above all, concentrates on studies of the molecular phenotype of rejection. This phenotype, rather than morphological characterization, may be c...